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【临床试验招募】肺癌比较Ipilimumab与安慰剂联合化疗治疗NSCLC的双盲试验

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题目和背景信息

适应症: 非小细胞肺癌
试验通俗题目: 比较Ipilimumab与安慰剂联合化疗治疗NSCLC的双盲试验
试验专业题目: 比较Ipilimumab与安慰剂联合紫杉醇和卡铂用于Ⅳ期/复发性NSCLC受试者的疗效的随机、多中心、双盲、3期试验
试验方案编号: CA184-104
临床申请受理号: 企业选择不公示
药物名称: 泰素
药物类型: 生物制品

临床试验信息

1、试验目的
本研究的目的是在非小细胞癌患者(仅鳞状细胞癌)中,观察接受Ipilimumab联合紫杉醇和卡铂治疗的患者的生存时间能否超过接受安慰剂联合紫杉醇和卡铂治疗的患者的生存期
2、试验设计(单选)
试验分类: 有效性
试验分期: III期
设计类型: 平行分组
随机化: 随机化
盲法: 双盲
试验范围: 国际多中心试验
3、受试者信息
年龄 18岁(最小年龄)至 N/A岁(最大年龄)
性别 男+女
健康受试者
入选标准
1 非小细胞肺癌(NSCLC)-鳞状细胞癌
2 ECOG体能状态≤1分
3 IV期或复发性NSCLC
4 IV期或复发性NSCLC
5 非小细胞肺癌(NSCLC)-鳞状细胞癌
6 ECOG体能状态≤1分
排除标准
1 自体免疫性疾病
2 脑转移
3 脑转移
4 自体免疫性疾病
目标入组人数 国际多中心试验:总体920人, 中国80人;
实际入组人数 国际多中心试验:总体923人,中国48人;
4、试验分组
试验药
序号 名称 用法
1 泰素 静脉注射液;规格100 mg/瓶;静脉注射(IV);用量:175 mg/m2,每3周第1天给药一次,连续使用6个周期
2 Ipilimumab注射液 (BMS) 静脉注射液;规格:200mg/40mL/瓶;静脉注射(IV);用量:10mg/kg,每3周一次,连续使用4个周期,之后每12周一次,直至疾病进展或发生不可接受的毒性
3 卡铂 静脉注射液;规格:450mg/瓶;静脉注射(IV);用量:AUC 6,每3周第1天给药一次,连续使用6个周期
4 卡铂(BMS) 注射液,规格150mg/15ml/支。按AUC = 6静脉输液,须在30分钟内完成输液。诱导期第1天开始每3周给药一次,最多6次剂量
5 紫杉醇(BMS) 注射液,规格5ml:30mg。按175 mg/m2静脉输液,须在3小时内完成输液。诱导期第1天开始每3周给药一次,最多6次剂量
6 Ipilimumab注射液 (BMS) 规格200mg/40ml。用容量泵通过0.2至1.2um管线内滤器,按10 mg/kg静脉输液给药,必须在90min内完成输液,之后使用足量的生理盐水(约30 -50 mL)完全冲洗给药装置中的残留液体。诱导期每3周给药一次,最多4次。维持期每12周给药一次
对照药
序号 名称 用法
1 安慰剂0.9%氯化钠注射液(研究中心自备) 静脉注射液;规格:200mg/40mL/瓶;静脉注射(IV);用量:10mg/kg;每3周一次,连续使用4个周期,之后每12周一次,直至疾病进展或发生不可接受的毒性
2 卡铂 静脉注射液;规格:450mg/瓶;静脉注射(IV);用量:AUC 6,每3周第1天给药一次,连续使用6个周期
3 泰素 静脉注射液;规格100 mg/瓶;静脉注射(IV);用量:175 mg/m2,每3周第1天给药一次,连续使用6个周期
4 紫杉醇(BMS) 注射液,规格5ml:30mg。按175 mg/m2静脉输液,须在3小时内完成输液。诱导期第1天开始每3周给药一次,最多6次剂量
5 安慰剂注射液(研究中心自备) 0.9%氯化钠注射液or 5%葡萄糖水溶液静脉输液,须在90分钟内完成输液,诱导期每3周给药一次,最多4次剂量。维持期每12周给药一次
6 卡铂(BMS) 注射液,规格150mg/15ml/支。按AUC = 6静脉输液,须在30分钟内完成输液。诱导期第1天开始每3周给药一次,最多6次剂量
5、终点指标
主要终点指标及评价时间
序号 指标 评价时间 终点指标选择
1 总生存期 705死亡事件(观察到528例死亡事件后进行一次中期分析) 有效性指标
次要终点指标及评价时间
序号 指标 评价时间 终点指标选择
1 接受了至少一剂盲态研究治疗的所有随机分组受试者中的OS (OS2) 研究开始后的42个月内 有效性指标
2 根据mWHO标准的最佳总体缓解率 研究开始后的42个月内 有效性指标
3 根据mWHO标准的无进展生存期 研究开始后的42个月内 有效性指标
6、数据安全监察委员会(DMC): 有
7、为受试者购买试验伤害保险: 有

研究者信息

各参加机构信息
序号 机构名称 国家 省(州) 城市
1 中山大学肿瘤防治中心 中国 广东 广州
2 天津市肿瘤医院 中国 天津 天津
3 中国人民解放军第三〇七医院 中国 北京 北京
4 中国医学科学院肿瘤医院 中国 北京 北京
5 北京大学肿瘤医院 中国 北京 北京
6 西安交通大学医学院第一附属医院 中国 陕西 西安
7 吉林省肿瘤医院 中国 吉林 长春
8 同济大学附属上海市肺科医院 中国 上海 上海
9 浙江大学医学院附属邵逸夫医院 中国 浙江 杭州
10 中国人民解放军第八一医院 中国 江苏 南京
11 中国人民解放军第四军医大学唐都医院 中国 陕西 西安
12 新疆医科大学附属肿瘤医院 中国 新疆 乌鲁木齐
13 中国人民解放军总医院 中国 北京 北京
14 中国医科大学附属第一医院 中国 辽宁 沈阳
15 苏州大学附属第一医院 中国 江苏 苏州
16 浙江大学医学院附属第二医院 中国 浙江 杭州
17 华中科技大学同济医学院附属协和医院 中国 湖北 武汉
18 汕头大学医学院附属肿瘤医院 中国 广东 汕头
19 江苏省肿瘤医院 中国 江苏 南京
20 上海交通大学附属胸科医院 中国 上海 上海
21 北京协和医院 中国 北京 北京
22 广东省人民医院 中国 广东 广州
23 Sanatorio Parque S.A. Privado Argentina CORDOBA Cordoba
24 Centro Oncologico De Intergracion Regional Argentina MENDOZA Mendoza
25 Centro Esecializado Isis Argentina SANTA FE Santa Fe
26 Sanatorio Parque Argentina SANTA FE Rosario
27 Centro Para La Atencion Integral Del Paciente Oncologico Argentina TUCUMAN San Miguel De Tucuman
28 Instituto Oncologico De Cordoba Argentina CORDOBA Cordoba
29 Cer Instituto Medico Argentina BUENOS AIRES Quilmes
30 North Coast Cancer Australia Victoria Lismore
31 Peninsula Oncology Centre Australia Victoria Frankston
32 Austin Hospital Australia Victoria Heidelberg
33 Flinders Medical Centre Australia South Australia Bedford Park
34 Box Hill Hospital Australia Victoria Box Hill
35 Border Medical Oncology Australia Victoria Wodonga
36 Mount Medical Centre, Perth Oncology Australia Western Australia Perth
37 Krankenhaus Der Elisabethinen Linz GmbH Austria Linz Linz
38 Salzburger Landeskliniken Lkh Austria Salzburg Salzburg
39 Allgemeines Krankenhaus Linz Austria Linz Linz
40 Medizinische Universitaet Graz, Austria Graz Graz
41 Centre Hospitalier Regional De La Citadelle Belgium Liege Liege
42 Az Nikolaas Belgium Sint Niklaas Sint Niklaas
43 Cliniques Universitaires Ucl De Mont-Godinne Belgium Yvoir Yvoir
44 Algemeen Stedelijk Ziekenhuis Aalst Belgium Aalst Aalst
45 Onze Lieve Vrouwenziekenhuis Campus Aalst Belgium Aalst Aalst
46 Oncoclinic - Clinica De Oncologia E Atendimento De Urgencia Brazil Ceara Fortaleza
47 Liga Paranaense De Combate Ao Cancer Erasto Gaertner Brazil Parana Curitiba
48 Instituto Ribeirao Pretano De Combate Ao Cancer - Irpcc Brazil Sao Paulo Ribeirao Preto
49 Instituto De Oncologia Do Vale Brazil Sao Paulo Sao Jose dos Campos
50 Instituto De Assistencia Medica Ao Servidor Publico Estadual Brazil Sao Paulo Sao Paulo
51 Hospital Da Cidade Brazil Rio Grande do Sul Passo Fundo
52 Gram Grupo De Assistencia Medica E Prestacao De Servicos Brazil Sao Paulo Sao Paulo
53 Trymed-Biocancer Centro de Pesquisa Clinica S.A. Brazil Belo Horizonte Belo Horizonte
54 Fundacao Pio Xii Hosp Cancer De Barretos Brazil Sao Paulo Barretos
55 Hospital Sao Vicente De Paulo Brazil Rio Grande Do Sul Passo Fundo
56 Instituto Nacional Do Cancer - Inca Brazil Rio de janeiro Rio de Janeiro
57 Clinionco Brazil Rio Grande Do Sul Porto Alegre
58 Jewish General Hospital Canada Qc Montreal
59 Hopital Du Sacre-Coeur De Montreal Canada Qc Montreal
60 Gerald Bronfman Centre Canada Qc Montreal
61 Reg Cancer Program Of The Hopital De Sudbury Regional Hosp Canada On Sudbury
62 Lakeridge Health RS McLaughlin Durham Regional Cancer Centre Canada Oshawa Oshawa
63 Instituto Nacional Del Cancer Chile METROPOLITANA Santiago
64 Centro De Investigacion Clinica Chile METROPOLITANA Santiago
65 Instituto Oncologico Clinica Renaca Chile VALPARAISO Vina Del Mar
66 Clinica Santa Maria Chile METROPOLITANA Santiago
67 Oncomedica S. A. Colombia CORDOBA Monteria
68 Fundacion Cardiovascular De Colombia Colombia SANTANDER Bucaramanga
69 Oncologos De Occidente S.A Colombia RISARALDA Pereira
70 Nemocnice na Bulovce Czech Republic Prague 8 - Liben Prague 8 - Liben
71 Oblastni Nemocnice Pribram, A.S. Czech Republic Pribram Pribram
72 Fn Motol, Pneumologicka Klinika Uk Czech Republic Praha 5 Praha 5
73 Nemocnice Znojmo, Odd. Radiacni A Klinicke Onkologie Czech Republic Znojmo Znojmo
74 MasarykovaNemocnice V Usti Nad Labem Czech Republic Usti Nad Labem Usti Nad Labem
75 Fakultni Nemocnice Ostrava Czech Republic Ostrava Ostrava
76 General University Hospital in Prague Czech Republic Prague 2 Prague 2
77 Herlev Hospital Denmark Herlev Herlev
78 Odense University Hospital Denmark Odense Odense
79 Naestved Hospital Denmark Naestved Naestved
80 Aalborg Hospital Denmark Aalborg Aalborg
81 Hillerod Hospital Denmark Hillerod Hillerod
82 Hopital Nord France Marseille Cedex 20 Marseille Cedex 20
83 Chu Toulouse France Toulouse Cedex 9 Toulouse Cedex 9
84 Centre Hospitalier Intercommunal de Creteil France Creteil Creteil
85 Hopital De Brabois France Vandoeuvre-les-nancy Vandoeuvre-les-nancy
86 Centre Francois Baclesse France Caen Caen
87 Chu De Poitiers France Poitiers Poitiers
88 Chu Pontchaillou France Rennes Cedex 9 Rennes Cedex 9
89 Groupe Hospitalier Paris St-Joseph France Paris Paris
90 Augusta-Kranken-Anstalt Ggmbh Germany Bochum Bochum
91 Klinikum Darmstadt GmbH Germany Darmstadt Darmstadt
92 Universitatsklinikum Schleswig Holstein Germany Lubeck Lubeck
93 Klinikum Nuernberg Germany Nuernberg Nuernberg
94 Schwarzwald Baar Klinikum Germany Villingen Schwenningen Villingen Schwenningen
95 Kliniken Der Stadt Koeln Ggmbh Krankenhaus Mehrheim Germany Koeln Koeln
96 Asklepios Klinik Harburg Lungenabteilung Germany Hamburg Hamburg
97 Universitaetsklinikum Carl Gustav Carus Germany Dresden Dresden
98 Klinikum Der Johann Wolfgang Goethe-Universitat Germany Frankfurt am Main Frankfurt am Main
99 Pius-Hospital Oldenburg Germany Oldenburg Oldenburg
100 Friedrich Ebert Krankenhaus Gmbh Germany Neumunster Neumunster
101 Medizinische Universitaetsklinik Tuebingen Germany Tuebingen Tuebingen
102 Universitaetsklinikum Ulm Germany Ulm Ulm
103 Krankenhaus Grosshansdorf Gmbh Germany Grosshansdorf Grosshansdorf
104 Zentralklinik Bad Berka Gmbh Germany Bad Berka Bad Berka
105 Klinikum Bogenhausen Germany Muenchen Muenchen
106 Lungenklinik Hemer Germany Hemer Hemer
107 Krankenhaus Barmherzige Brueder Regensburg Germany Regensburg Regensburg
108 Thoraxklinik-Heidelberg Ggmbh Germany Heidelberg Heidelberg
109 Asklepius Fachkliniken Germany Gauting Gauting
110 Universitaetsmedizin Der Johannes Gutenberg-Universitaet Germany Mainz Mainz
111 Klinikum Kassel Gmbh Germany Kassel Kassel
112 Pamela Youde Nethersole Eastern Hospital 中国 香港 香港
113 Queen Mary Hospital 中国 香港 香港
114 Tuen Mun Hospital 中国 香港 香港
115 Queen Elizabeth Hospital 中国 香港 香港
116 Matrai Gyogyintezet Hungary Matrahaza Matrahaza
117 Sopron Megyei Jogu Varos Erzsebet Oktato Korhaz Hungary Sopron Sopron
118 Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointez Hungary Szolnok Szolnok
119 Semmelweis Egyetem, Pulmonologiai Klinika Hungary Budapest Budapest
120 Veszprem Megyei Onkormanyzat Tudogyogyintezete Hungary Farkasgyepu Farkasgyepu
121 Orszagos Koranyi Tbc Es Pulmonologiai Intezet Hungary Budapest Budapest
122 Fejer Megyei Szent Gyorgy Korhaz Hungary Szekesfehervar Szekesfehervar
123 Pte Klinikai Kozpont 1.Sz. Belgyogyaszati Klinika, Pulmonolo Hungary Pecs Pecs
124 Csongrad Megyei Onkormanyzat Mellkasi Betegsegek Szakkorhaza Hungary Deszk Deszk
125 Josa Andras Oktatokorhaz Hungary Nyiregyhaza Nyiregyhaza
126 Bekes Megyei Kepviselotestulet Pandy Kalman Korhaz Hungary Gyula Gyula
127 Pest Megyei Tudogyogyintezet Hungary Torokbalint Torokbalint
128 St James Hospital Ireland Dublin Dublin
129 GalWay University Hospital Ireland Galway Galway
130 St Vincent's University Hospital Ireland Dublin Dublin
131 Adelaide Meath National Childrens Hospital Ireland Dublin Dublin
132 The Soroka University Medical Center Israel Beer Sheva Beer Sheva
133 Assaf Harofeh Medical Center Israel Zerifin Zerifin
134 Meir Medical Center Israel Kfar Saba Kfar Saba
135 Assuta Medical Center, Oncology Department Israel Tel-aviv Tel-aviv
136 Oncology Institute, Kaplan Medical Center Israel Rehovot Rehovot
137 Tel-Aviv Sourasky Medical Center Israel Tel-aviv Tel-aviv
138 Western Galilee Hospital- Nahariya Israel Nahariya Nahariya
139 Oncology Department, Hadassah Medical Organization Israel Jerusalem Jerusalem
140 Oncology Institute, Sheba Medical Center Israel Ramat-gan Ramat-gan
141 The Davidoff Comprehensive Cancer Center Israel Petah-tikva Petah-tikva
142 Oncology Institute, Rambam Medical Center Israel Haifa Haifa
143 Ospedale Versilia Italy Lucca Lido Di Camaiore
144 Ospedale Campo Di Marte Italy Lucca Lucca
145 Azienda Ospedaliera Treviglio-Caravaggio Italy Treviglio Treviglio
146 Ospedale Civile Di Sondrio - Azienda Ospedaliera Della Italy Sondrio Sondrio
147 Azienda Ospedaliera - Nuovo Ospedale San Gerardo Italy Monza Monza
148 Azienda Ospedaliera Di Perugia Italy Perugia Perugia
149 Ospedale G.Rummo Italy Benevento Benevento
150 I.O.V. Istituto Oncologico Veneto Ircss Italy Padova Padova
151 Azienda Ospedaliera Universitaria Senese Italy Siena Siena
152 Policlinico S. Orsola Malpighi Italy Bologna Bologna
153 Ospedale S.Maria Italy Terni Terni
154 Miyagi Cancer Center Japan Miyagi Natori-shi
155 Aichi Cancer Center Central Hospital Japan Aichi Nagoya
156 Kanazawa University Hospital Japan ISHIKAWA Kanazawa-shi
157 Kanagawa Cardiovascular and Respiratory Center Japan Kanagawa Yokohama-Shi
158 National Cancer Center Hospital East Japan CHIBA Kashiwa
159 Yokohama Municipal Citizen's Hospital/Respiratory Internal Medicine Japan Kanagawa Yokohama-Shi
160 National Hospital Organization Nagoya Medical Center Japan Aichi Nagoya-shi
161 National Nagoya Hospital Japan Aichi Nagoya-shi
162 Kyushu University Hospital Japan FUKUOKA Fukuoka-shi
163 National Hospital Organization Kyushu Med Ctr Japan FUKUOKA Fukuoka-shi
164 Osaka Medical College Hospital Japan OSAKA Takatsuki-shi
165 Kansai Medical University Hirakata Hospital Japan OSAKA Hirakata-shi
166 Shizuoka Cancer Center Japan Shizuoka Sunto-gun
167 Kinki University School Of Medicine Japan OSAKA Osaka-sayama-shi
168 Kawasaki Medical School Hospital Japan OKAYAMA Kurashiki City
169 Osaka City General Hospital Japan OSAKA Osaka-shi
170 Kurashiki Central Hospital Japan OKAYAMA Kurashiki-shi
171 Yamaguchi Ube Medical Center Japan Yamaguchi Ube-shi
172 Hokkaido Cancer Center Japan Sapporo, Hokkaido Sapporo, Hokkaido
173 Tohoku University Hospital Japan Sendai Sendai
174 Hokkaido University Hospital Japan Sapporo, Hokkaido Sapporo, Hokkaido
175 Shikoku Cancer Center Japan Matsuyama, Ehime Matsuyama, Ehime
176 Cancer Institute Hospital Of Jfcr Japan Tokyo Koto-ku
177 Hyogo Cancer Center Japan Akashi, Hyogo Akashi, Hyogo
178 Sendai Kosei Hospital Japan Sendai, Miyagi Sendai, Miyagi
179 National Cancer Center Hospital Japan Tokyo Chuo-ku
180 Div Of Hematology & Oncology, Dept Of Med, Samsung Med Cntr Republic of Korea Seoul Seoul
181 Gangnam Severance Hospital, Younsei University Health System Republic of Korea Seoul Seoul
182 Pusan National University Hospital Republic of Korea BUSAN BUSAN
183 Chung-Ang University Hospital Republic of Korea Seoul Seoul
184 Seoul St. Mary'S Hospital, The Catholic University Of Korea Republic of Korea Seoul Seoul
185 VHS Medical Center Republic of Korea Seoul Seoul
186 Seoul National University Hospital Republic of Korea Seoul Seoul
187 The Catholic University Of Korea St. Vincent'S Hosp Republic of Korea GYEONGGI-DO Suwon-si
188 Severance Hospital, Yonsei University Health System Republic of Korea Seoul Seoul
189 Asan Medical Center Republic of Korea Seoul Seoul
190 Ajou University Hospital Republic of Korea GYEONGGI-DO Suwon
191 Seoul National University Bundang Hospital Republic of Korea Seongnam-si Seongnam-si
192 Chungbuk National University Hospital Republic of Korea Cheogju-si Cheogju-si
193 National Cancer Center Republic of Korea GYEONGGI-DO Goyang-si
194 Korea University Anam Hospital Republic of Korea Seoul SEOUL
195 Keimyung University Dongsan Medical Center Republic of Korea Daegu Daegu
196 Hospital Y Clinica Oca Mexico Nuevo Leon Monterrey
197 Althian Research Management Center Mexico Nuevo Leon Monterrey
198 Hospital General De Occidente Mexico Jalisco Zapopan
199 Centro Medico Dalinde Mexico Distrito Federal Mexico
200 Amphia Ziekenhuis ( Amphia Hospital) Netherlands Breda Breda
201 Jeroen Bosch Ziekenhuis (Jeroen Bosch Hospital) Netherlands 's-Hertogenbosch 's-Hertogenbosch
202 St. Jansdal Ziekenhuis Netherlands Harderwijk Harderwijk
203 St. Antonius Hospital Netherlands Nieuwegein Nieuwegein
204 Vu University Medical Center Netherlands Amsterdam Amsterdam
205 Hospital Nacional Dos De Mayo/ Unidad De Quimioterapia Peru Lima Lima
206 Hospital Nacional Edgardo Rebagliati Martins Peru Lima Lima
207 Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud Peru Arequipa Arequipa
208 Clinica Peruano Americana / Centro De Invest. Clin Trujillo Peru LA LIBERTAD Trujillo
209 Centrum Onkologii- Oddzial Kliniczny Onkologii Poland Bydgoszcz Bydgoszcz
210 Uniwersyteckie Centrum Kliniczne, Klinika Nefrologii,Transpl Poland Gdansk Gdansk
211 Spz Gruzlicy I Chorob Pluc W Olsztynie Poland Olsztyn Olsztyn
212 Centrum Onkologii - Instytut Im. Marii Sklodowskiej-Curie Poland Warszawa Warszawa
213 Szpital Morski Im. Pck Poland Gdynia Gdynia
214 Wojewodzkie Centrum Onkologii Sp Zoz Poland Gdansk Gdansk
215 Szpital Im. St. Leszczynskiego Poland Katowice Katowice
216 Oddzial Onkologii Klinicznej Poland Poznan Poznan
217 Wojewodzki Szpital Zespolony W Elblagu Poland Elblag Elblag
218 Regionalny Szpital Specjalistyczny W Grudziadzu Poland Grudziadz Grudziadz
219 Wojewodzki Szpital Zespolony Im. L. Rydygiera W Toruniu Poland Torun Torun
220 Specjalistyczny Szpital Im. Prof. Alfreda Sokolowskiego Poland Szczecin Szczecin
221 Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy Poland Otwock Otwock
222 Inst Portugues De Oncologia De Lisboa Francisco Gentil,E.P.E Portugal LISBOA Lisboa
223 Centro Hospitalar De Entre O Douro E Vouga, Epe Portugal SANTA MARIA DA FEIRA Santa Maria Da Feira
224 Centro Hospitalar De Coimbra Portugal Coimbra Coimbra
225 Centro Hospitalar De Vila Nova De Gaia/Espinho, Epe Portugal Vila Nova De Gaia Vila Nova De Gaia
226 Inst Portugues De Oncologia Do Porto Francisco Gentil, E.P.E Portugal PORTO Porto
227 Centro Hospitalar Lisboa Norte, Epe - Hospital De Santa Mari Portugal LISBOA Lisboa
228 Coltea Clinical Hospital Romania Bucharest Bucharest
229 Spitalul Judetean De Urgenta Romania Suceava Suceava
230 Ianuli Med Consult Srl Romania Bucuresti Bucuresti
231 Oncomed Romania Timisoara, Timis Timisoara, Timis
232 Spitalul Judetean De Urgenta Sibiu Romania Sibiu Sibiu
233 Sc Medisprof Srl Romania Cluj Napoca Cluj Napoca
234 Johns Hopkins International Medical Centre Singapore Singapore Singapore
235 Oncocare Cancer Centre Singapore Singapore Singapore
236 Sahlgrenska Ostra Hospital Sweden Gothenburg Gothenburg
237 Department Of Oncology Sweden Umea Umea
238 Skanes University Hospital Sweden Lund Lund
239 Dept Of Oncology Sweden Stockholm Stockholm
240 Guz Republic Clinical Oncology Dispensary By Moh In Tatarst Russian Federation Kazan Kazan
241 Guz Clinical Oncology Dispensary #1 Russian Federation Krasnodar Krasnodar
242 State Institution Of Healthcare Russian Federation Tula Tula
243 Russian Scientific Center Of Rentgenoradiology Russian Federation Moscow Moscow
244 Chelyabinsk Regional Oncology Dispensary Russian Federation Chelyabinsk Chelyabinsk
245 Russian Oncology Research Center Named After Blokhin N.N. Russian Federation Moscow Moscow
246 City Clinical Oncology Dispensary Russian Federation St-Peterburg St-Peterburg
247 Samara Regional Oncology Dispensary Russian Federation Samara Samara
248 Russian Oncological Research Center N.A. N.N. Blokhin Rams Russian Federation Moscow Moscow
249 Saint Petersburg State Medical University Russian Federation St. Petersburg St. Petersburg
250 Republic Clinical Oncology Dispensary of Ministry of Health of Republic Tatarsta Russian Federation Kazan Kazan
251 NII Oncology n.a. N.N. Petrov Russian Federation Saint Petersburg Saint Petersburg
252 FGBU Med. Radiol. Research Centre of Rus. Ministry of Health Russian Federation Obninsk Obninsk
253 Fgu Hospital With Polyclinic Russian Federation Moscow Moscow
254 State Healthcare Inst. Pyatigorsk Oncology Dispensary Russian Federation Pyatigorsk Pyatigorsk
255 Department Of Radiation Oncology South Africa WESTERN CAPE Observatory
256 GVI Oncology Clinical Trials Unit South Africa WESTERN CAPE Panorama,cape Town
257 G V I Oncology, Rondebosch Oncology Centre South Africa WESTERN CAPE Rondebosch
258 Hopelands Cancer Centre South Africa KWA ZULU NATAL Durban
259 Vaal Triangle Oncology-Alberts, Bouwer & Jordaan Inc. South Africa EASTERN CAPE Vereeniging
260 Centre Pluridisciplinaire D'Oncologie Centre Hosp Univ Switzerland Lausanne Lausanne
261 Kantonsspital Winterthur Switzerland Winterthur Winterthur
262 Onkologiezentrum Thun-Berner Oberland Spital Sts Ag Switzerland Thun Thun
263 University Hospital Basel Switzerland Basel Basel
264 Hospital Nuestra Senora. De Sonsoles Spain Avila Avila
265 Hospital General Univ De Valencia Spain Valencia Valencia
266 Althaia Xarxa Assistencial De Manresa Spain Manresa Manresa
267 Hospital Clinical Benidorm Spain Benidorm-alicante Benidorm-alicante
268 Hospital Santa Maria Nai Spain Ourense Ourense
269 Hospital Arnau De Vilanova Spain Valencia Valencia
270 Hospital 12 De Octubre Spain Madrid Madrid
271 Hospital De Mataro Spain Barcelona Barcelona
272 Hospital De Cruces Spain Vizcaya Vizcaya
273 Hospital Provincial De Castellon Spain Castellon Castellon
274 Hospital Md Anderson Spain Madrid Madrid
275 Taichung Veterans General Hospital 中国 台湾 Taichung
276 China Medical University Hospital 中国 台湾 Taichung City
277 Chang Gung Medical Foundation, Linkou Branch 中国 台湾 Taoyuan
278 Changhua Christian Hospital 中国 台湾 Changhua
279 Chang Gung Medical Foundation-Chiayi Branch 中国 台湾 Chiayi
280 Taipei Veterans General Hospital 中国 台湾 Taipei
281 Chang Gung Medical Foundation-Kaohsiung Branch 中国 台湾 Kaohsiung
282 National Taiwan University Hospital 中国 台湾 Taipei
283 National Cancer Institute, Medical Oncology Unit Thailand Bangkok Bangkok
284 Holistic Center For Cancer Study And Care (Hocc-Psu) Thailand Songkla Songkla
285 Phramongkutklao Hospital Thailand Bangkok Bangkok
286 Division Of Medical Oncology Unit, Department Of Medicine Thailand Bangkok Bangkok
287 Faculty Of Medicine, Chulalongkorn University Thailand Bangkok Bangkok
288 Div. Of Medical Oncology, Dept. Of Medicine, Faculty Of Med Thailand Chiang Mai Chiang Mai
289 Royal Surrey County Hospital United Kingdom Surrey Guildford
290 Southampton University Hospital Nhs Trust United Kingdom Hampshire Southampton
291 The Royal Marsden Hospital United Kingdom Greater London London
292 Nottingham University Hospitals Nhs Trust United Kingdom Nottinghamshire Nottingham
293 Ninewells Hospital And Medical School United Kingdom Angus/forfarshire Dundee
294 Royal Cornwall Hospital United Kingdom Cornwall Truro
295 Weston Park Hospital United Kingdom Sheffield Sheffield
296 Sharp Memorial Hospital USA CA San Diego
297 Hematology & Med Oncology Of Southern Palm Beach County, Inc USA FL Boynton Beach
298 Va Connecticut Healthcare System USA FL Newington
299 Floyd Memorial Cancer Center Of Indiana USA CT New Albany
300 Lynn Cancer Institute Center For Hematology-Oncology USA IN Boca Raton
301 Integrated Community Oncology Network USA FL Jacksonville
302 Indiana University Cancer Center USA FL Indianapolis
303 Quincy Medical Group USA IL Quincy
304 University Of Illinois At Chicago Medical Center USA IL Chicago
305 Southern Illinois University School Of Medicine USA IL Springfield
306 Orchard Healthcare Research Inc. USA IL Skokie
307 St. Francis Hospital & Health Centers USA IN Beech Grove
308 Clinical Research Alliance, Inc. USA NY Lake Success
309 Syracuse Va Medical Center USA NY Syracuse
310 Kentucky Cancer Clinic USA KY Hazard
311 Norton Cancer Institute USA KY Louisville
312 Durham Va Medical Center USA NC Durham
313 Piedmont Hematology Oncology Associates, Pllc USA NC Winston Salem
314 Duke University Medical Center USA NC Butner
315 Carolina Biooncology Institute USA NC Huntersville
316 Presbyterian Hospital Cancer Research USA NC Charlotte
317 Montgomery Cancer Center USA KY Mount Sterling
318 Washington University School Of Medicine USA MO Saint Louis
319 Oklahoma Oncology And Hematology, Pc Dba USA OK Tulsa
320 Singing River Health System USA MS Pascagoula
321 University Of Minnesota USA MN Minneapolis
322 Gabrail Cancer Center Research USA OH Dover
323 Warren Cancer Research Foundation USA OK Tulsa
324 Kansas City Cancer Centers -South USA MO Kansas City
325 Dartmouth-Hitchcock Medical Center USA NH Lebanon
326 St Joseph Mercy Hospital USA MI Ann Arbor
327 Tennessee Cancer Specialists USA TN Knoxville
328 Associated in Oncology and Hematology USA TN Chattanooga
329 Cancer Center Of The Carolinas USA SC Easley
330 Cancer Center At Cookeville Regional Medical Center USA TN Cookeville
331 Thompson Oncology Group USA TN Knoxville
332 Providence Regional Med Cntr Everett/Cancer Partnership USA WA Everett
333 Texas Oncology, PA - South Austin Cancer Center USA TX Austin
334 Wjb Dorn Va Medical Center USA SC Columbia
335 Blue Ridge Cancer Care USA VA Salem
336 Guthrie Clinic, Ltd USA PA Sayre
337 Wisconsin Institutes for Medical Research USA WI Madison
338 Kaiser Permanente Northwest Region USA OR Portland
339 Cancer Outreach Associates, Pc USA VA Abingdon
340 广东省人民医院 中国 广东 广州
341 天津市肿瘤医院 中国 天津 天津
342 军事医学科学院附属医院 中国 北京 北京
343 中国医学科学院肿瘤医院 中国 北京 北京
344 北京大学肿瘤医院 中国 北京 北京
345 西安交通大学医学院第一附属医院 中国 陕西 西安
346 吉林省肿瘤医院 中国 吉林 长春
347 同济大学附属上海市肺科医院 中国 上海 上海
348 浙江大学医学院附属邵逸夫医院 中国 浙江 杭州
349 中国人民解放军第八一医院 中国 江苏 南京
350 四川大学华西医院 中国 四川 成都
351 中国人民解放军第四军医大学唐都医院 中国 陕西 西安
352 新疆医科大学附属肿瘤医院 中国 新疆 乌鲁木齐
353 中国人民解放军总医院 中国 北京 北京
354 中国医科大学附属第一医院 中国 辽宁 沈阳
355 苏州大学附属第一医院 中国 江苏 苏州
356 浙江大学医学院附属第二医院 中国 浙江 杭州
357 华中科技大学同济医学院附属协和医院 中国 湖北 武汉
358 汕头大学医学院附属肿瘤医院 中国 广东 汕头
359 江苏省肿瘤医院 中国 江苏 南京
360 上海交通大学附属胸科医院 中国 上海 上海
361 北京协和医院 中国 北京 北京

信息声明

*以上临床试验信息摘自国家药品监督管理局药品审评中心临床试验登记与信息公示平台

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